St. Gregorios College is located at about 750 meters towards east from Pulamon Junction, Kottarakara, the point where the MC Road intersects with the National Highway 208 (Kollam-Tirumangalam Road). A brief walk of about 250 meters from Pulamon Junction through the NH proceeding to Punalur, will take you to the College Junction (near St. Ignatious Church, Kottapuram). From there, the rightward proceeding tar road will take you to the college. Pulamon Junction, Kottarakara is located at about 72km from Thiruvananthapuram (MC Road), 26 km from Kollam (NH208), 20 km from Adoor (MC Road), and 19 km from Punalur (NH208). It is adjoining to Kottarakara KSRTC Bus Station, just 2.4 km from Kottarakara Railway Station and about 73 km from Thiruvananthapuram International Airport.